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A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33

Petersen, Gloria M (author)
Amundadottir, Laufey (author)
Fuchs, Charles S (author)
show more...
Kraft, Peter (author)
Stolzenberg-Solomon, Rachael Z (author)
Jacobs, Kevin B (author)
Arslan, Alan A (author)
Bueno-de-Mesquita, H Bas (author)
Gallinger, Steven (author)
Gross, Myron (author)
Helzlsouer, Kathy (author)
Holly, Elizabeth A (author)
Jacobs, Eric J (author)
Klein, Alison P (author)
LaCroix, Andrea (author)
Li, Donghui (author)
Mandelson, Margaret T (author)
Olson, Sara H (author)
Risch, Harvey A (author)
Zheng, Wei (author)
Albanes, Demetrius (author)
Bamlet, William R (author)
Berg, Christine D (author)
Boutron-Ruault, Marie-Christine (author)
Buring, Julie E (author)
Bracci, Paige M (author)
Canzian, Federico (author)
Clipp, Sandra (author)
Cotterchio, Michelle (author)
de Andrade, Mariza (author)
Duell, Eric J (author)
Gaziano, J Michael (author)
Giovannucci, Edward L (author)
Goggins, Michael (author)
Hallmans, Göran, 1947- (author)
Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Näringsforskning
Hankinson, Susan E (author)
Hassan, Manal (author)
Howard, Barbara (author)
Hunter, David J (author)
Hutchinson, Amy (author)
Jenab, Mazda (author)
Kaaks, Rudolf (author)
Kooperberg, Charles (author)
Krogh, Vittorio (author)
Kurtz, Robert C (author)
Lynch, Shannon M (author)
McWilliams, Robert R (author)
Mendelsohn, Julie B (author)
Michaud, Dominique S (author)
Parikh, Hemang (author)
Patel, Alpa V (author)
Peeters, Petra H M (author)
Rajkovic, Aleksandar (author)
Riboli, Elio (author)
Rodriguez, Laudina (author)
Seminara, Daniela (author)
Shu, Xiao-Ou (author)
Thomas, Gilles (author)
Tjønneland, Anne (author)
Tobias, Geoffrey S (author)
Trichopoulos, Dimitrios (author)
Van Den Eeden, Stephen K (author)
Virtamo, Jarmo (author)
Wactawski-Wende, Jean (author)
Wang, Zhaoming (author)
Wolpin, Brian M (author)
Yu, Herbert (author)
Yu, Kai (author)
Zeleniuch-Jacquotte, Anne (author)
Fraumeni, Joseph F (author)
Hoover, Robert N (author)
Hartge, Patricia (author)
Chanock, Stephen J (author)
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 (creator_code:org_t)
2010-01-24
2010
English.
In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:3, s. 224-228
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.

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